Description: The gut microbiome is a very important modulator of metabolic processes as it affects the absorption of nutrients, sensitivity to insulin, and the storage of fat. New evidence emphasizes the modulatory effects of gut microbiota towards inflammation and endocrine signaling that culminate in insulin resistance and metabolic dysfunction. Some therapeutic strategies include probiotics, prebiotics, and dietary interventions that focus on restoring the normal gut microbiome to enhance metabolic health. The gut microbiome's influence opens new avenues for personalizing treatments in metabolic diseases. Experts will discuss novel therapeutic strategies to improve patient outcomes by discussing the latest knowledge related to gut microbiome in metabolic diseases.