Description: Obesity has a very significant impact on endocrine health because it disrupts the balance of hormones, leading to metabolic disorders such as type 2 diabetes, thyroid dysfunction, and polycystic ovary syndrome. Excess adiposity from obesity changes how insulin, cortisol, and sex hormones work, thus increasing vulnerability to chronic diseases. At DEWC, this connection between obesity and endocrine health will be presented so that new strategies for prevention and treatment can be envisioned for this growing public health challenge. Recent studies have focused on understanding how adipose tissue impacts endocrine signaling and metabolism, pointing to inflammation and insulin resistance as critical mechanisms. Lifestyle interventions for weight loss, pharmacotherapy, and bariatric surgery all lead to improved endocrine function and decreased risk for many diseases. New drugs will target the hormonal disturbances due to obesity.