Speakers - DEWC2025

Abstract

Objectives:

Thyroid hormones and triglycerides (TG) are associated with HDP. Triiodothyronine (T3) is the bioactive form of thyroid hormone, and the relationship between T3 in early pregnancy and HDP remains unclear. This study aimed to investigate the potential association between T3 and the incidence of HDP, while also exploring whether TG serve as a mediating factor in this relationship.

Methods:

The study included 13,915 pregnant women who underwent prenatal screening between January 2020 and December 2021. Logistic regression analyses were conducted to explore the relationship between T3, TG, and HDP. Causal mediation analysis was performed to investigate the mediating role of TG in the relationship between T3 and HDP.

Results:

We found that higher levels of free triiodothyronine (FT3), total triiodothyronine (TT3), and TG in early pregnancy were associated with an increased risk of HDP (all P < 0.05). Positive correlations were also observed between FT3, TT3, and TG (all P < 0.05). Mediation analysis revealed that TG mediated 32.5% of the total effect of TT3 on HDP through the average causal mediation effect. Subgroup analyses, which classified HDP into preeclampsia (PE) and gestational hypertension (GH), further indicated that TG acted as a mediator in the relationships between FT3, TT3, and PE, with mediation proportions of 17.7% and 28.8%, respectively. Among participants without overweight or obesity or gestational diabetes mellitus, the mediation effect remained significant.

Conclusions:

Higher levels of T3 in early pregnancy increase the risk of HDP, particularly PE, with TG playing an important mediating role in this relationship.